Top 5 One Health Initiatives In 2025

As the world enters a new phase of global health collaboration, One Health Initiatives highlight a renewed focus on the shared responsibility of protecting people, animals, and the planet. With growing challenges like antimicrobial resistance, zoonotic outbreaks, and climate-related health threats, integrated solutions are more important than ever. At Mygotovet, we understand that animal health directly impacts human well-being, and we’re committed to supporting a healthier, safer world through veterinary innovation, public health awareness, and sustainable practices.

The One Health concept emphasizes the interconnection between humans, animals, and the environment. In 2025, this idea is no longer theoretical, it’s transforming into concrete action. Governments, international organizations, and private sectors are joining forces to create a stronger and more coordinated global health system. Let’s explore the Top 5 One Health Initiatives in 2025 that are driving this global transformation.

1. Strengthening Antimicrobial Resistance (AMR) Governance Worldwide

Antimicrobial resistance remains one of the most critical One Health challenges. Without effective antibiotics, both human and veterinary medicine could face severe setbacks. The first major One Health initiative in 2025 focuses on updating the Global Action Plan (GAP) on AMR, which aims to improve governance, enhance multisectoral collaboration, and promote responsible antimicrobial use.

The Quadripartite collaboration, comprising the WHO, FAO, WOAH, and UNEP, leads this effort. Their goal is to reduce AMR-related deaths by at least 10% by 2030 through improved policies, funding, and accountability frameworks. Additionally, the Independent Panel for Evidence for Action against AMR (IPEA), being established in 2025, will provide countries with science-based recommendations for tackling AMR across human, animal, and environmental sectors.

Mygotovet believes veterinary professionals play a vital role in antimicrobial stewardship. By promoting rational drug use and strengthening awareness among livestock and pet owners, we help minimize resistance risks while preserving treatment effectiveness for future generations.

2. U.S. National One Health Framework (2025–2029): A Model for Collaboration

The second major initiative on our list is the U.S. National One Health Framework (2025–2029). Launched in January 2025, this framework unites the Centers for Disease Control and Prevention (CDC), U.S. Department of Agriculture (USDA), and Department of the Interior (DOI) to build a resilient system against zoonotic diseases such as Ebola, Avian Influenza, and Rift Valley Fever.

Unlike past fragmented approaches, this framework focuses on coordination and rapid response. It encourages the creation of an Office of the One Health Coordinator within the Executive Office of the President, a move that would centralize decision-making, enhance surveillance, and integrate veterinary insights into national health planning.

This collaboration sets a new precedent for countries worldwide, showing that sustained political will and intersectoral unity can prevent future pandemics before they escalate. Through this model, One Health evolves from concept to action, aligning public health, animal health, and environmental protection into one strong system.

3. The Pandemic Fund: Financing Global Preparedness

While policy and governance are crucial, funding remains the lifeblood of implementation. The third major One Health initiative in 2025 is the expansion of the Pandemic Fund, a global financing mechanism aimed at improving pandemic prevention, preparedness, and response (PPR), especially in low- and middle-income countries.

This year, the second and third funding rounds are unlocking millions in grants for strengthening early warning systems, surveillance networks, and laboratory diagnostics. Over 32 projects worth more than $165 million are being co-led by the FAO, helping nations identify and control zoonotic threats before they spread.

By building local capacities and supporting animal health infrastructure in vulnerable regions, the world reduces the risk of outbreaks that could otherwise become global crises. It’s a powerful reminder that when every country is prepared, the entire world becomes safer.

4. Ethiopia’s National One Health Strategic Plan (2025/26–2029/30)

National commitment forms the backbone of global One Health implementation. In October 2025, Ethiopia made a bold move by launching its Five-Year National One Health Strategic Plan, estimated to cost $43.8 million. This comprehensive roadmap aims to reduce mortality caused by AMR and zoonotic diseases while improving environmental health and food safety.

The plan is structured around six strategic pillars:

1. Strengthening governance, capacity building, and research.

2. Improving disease preparedness and surveillance.

3. Enhancing food safety management.

4. Containing antimicrobial resistance.

5. Building socio-ecological resilience.

6. Boosting risk communication and community engagement.

This initiative stands out because it emphasizes local ownership and community participation. By involving ministries of health, agriculture, and environment, Ethiopia is creating a scalable model that can inspire other low- and middle-income nations. Through such practical action, the vision of One Health becomes achievable, tangible, and inclusive.

5. Securing Borders through the One Health Transboundary Assessment (OHTAPZ) Tool

The final entry in the Top 5 One Health Initiatives in 2025 is the One Health Transboundary Assessment for Priority Zoonoses (OHTAPZ) tool. Launched in late 2025, OHTAPZ helps countries assess and improve communication and coordination at border points, especially at airports and land crossings where zoonotic pathogens can easily spread.

The tool uses a five-phase framework, including stakeholder mapping, systems analysis, and simulation exercises, to identify gaps in border health security. By integrating human, animal, and environmental data, OHTAPZ helps nations comply with international health regulations while preventing cross-border outbreaks.

Looking Ahead: Collaboration for a Healthier Planet

The Health Initiatives clearly demonstrate that global health is evolving into a shared responsibility. Each initiative, from global AMR governance to national strategic plans and cross-border security, emphasizes one truth: no single sector can protect the planet alone.

As the world strengthens these partnerships, organizations like Mygotovet continue to bridge the gap between veterinary science and public health. Through education, innovation, and community engagement, Mygotovet contributes to the One Health mission, ensuring that humans, animals, and ecosystems thrive together.

The future of health depends on collaboration. Governments must invest in integrated systems, veterinarians must champion responsible care, and individuals must adopt sustainable habits. Together, we can transform global resilience from an aspiration into reality.

If you’re ready to be part of this movement, join Mygotovet in advancing the One Health vision, because protecting one life means protecting all.

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Frequently Asked Questions on One Health Initiatives in 2025

1. What are the top One Health initiatives in 2025?

The top One Health initiatives in 2025 include global antimicrobial resistance (AMR) governance reforms, the U.S. National One Health Framework, the Pandemic Fund expansion, Ethiopia’s Five-Year One Health Strategic Plan, and the One Health Transboundary Assessment for Priority Zoonoses (OHTAPZ) tool. Together, these programs strengthen global health resilience and promote collaboration across human, animal, and environmental sectors.

2. Why is One Health important in 2025?

One Health is crucial in 2025 because it integrates human, animal, and environmental health to address global threats like zoonotic diseases, antimicrobial resistance, and climate change. This holistic approach helps countries prevent pandemics, improve food safety, and protect ecosystems, making global health systems more sustainable and effective.

3. What organizations are leading One Health efforts in 2025?

The Quadripartite collaboration, comprising the World Health Organization (WHO), Food and Agriculture Organization (FAO), World Organisation for Animal Health (WOAH), and the United Nations Environment Programme (UNEP), is leading One Health efforts globally in 2025. They coordinate research, policy, and funding to strengthen health systems under the One Health framework.

4. How does the U.S. National One Health Framework improve public health?

The U.S. National One Health Framework (2025–2029) enhances public health by coordinating the efforts of the CDC, USDA, and DOI to monitor and prevent zoonotic diseases. It focuses on early detection, integrated data sharing, and preparedness, reducing the risk of pandemics and improving national response capacity.

5. How does the Pandemic Fund support One Health initiatives?

The Pandemic Fund provides financial resources to low- and middle-income countries for strengthening surveillance, laboratory capacity, and outbreak response. In 2025, over 32 projects worth $165 million are being implemented, ensuring equitable access to health security tools under the One Health approach.

6. What is Ethiopia’s One Health Strategic Plan?

Ethiopia’s Five-Year One Health Strategic Plan (2025/26–2029/30) is a national roadmap to reduce zoonotic diseases, improve food safety, and combat AMR. It involves multiple ministries and emphasizes governance, resilience, and risk communication to ensure coordinated health responses across human, animal, and environmental sectors.

7. What is the purpose of the OHTAPZ tool launched in 2025?

The One Health Transboundary Assessment for Priority Zoonoses (OHTAPZ) tool helps countries assess border health systems and improve communication between agencies. It enhances preparedness against transboundary diseases by identifying gaps, testing systems through simulations, and aligning with international health regulations.

8. How does One Health address antimicrobial resistance (AMR)?

One Health tackles AMR by promoting responsible antimicrobial use in humans, animals, and agriculture. It fosters surveillance, education, and policy integration to reduce misuse and preserve drug effectiveness. In 2025, the updated Global Action Plan on AMR prioritizes environmental monitoring and sustainable practices to curb resistance.

9: What is the future of One Health beyond 2025?

Beyond 2025, One Health will focus on digital health integration, climate adaptation, and cross-sectoral funding to build a resilient global system. With continued collaboration among governments, institutions, and private organizations like Mygotovet, the world can achieve long-term sustainability and health security.